Randomized Clinical Trial Corroborates Positive Effects of Charlotte’s Web Original Formula
In accordance with the company’s resolute commitment to enhancing knowledge through scientific rigor, Charlotte’s Web™ recently took part in a large-scale clinical study performed by an independent third party to evaluate the effectiveness of Original Formula, its flagship full spectrum hemp extract.
The study was an open label, randomized controlled trial conducted by Radicle Science as part of the Radicle ACES (Advancing CBD Education and Science) health outcomes initiative. Within this larger trial, 208 participants took on average 1.8 servings per day of Charlotte’s Web Original Formula for four weeks.
Participants were assessed at baseline and regularly throughout the study period using standardized, validated measures for key health outcomes across five overarching domains: general well-being; quality of life (QoL); sleep quality; pain and discomfort; and feelings of anxiety.
The study found that participants taking Charlotte’s Web Original Formula experienced statistically significant, clinically meaningful improvements in QoL and general well-being, as well as distinct and palpable improvements in each of the health outcomes measured when compared to the control group.
Improvements in Symptoms of Anxiety
64% of participants with symptoms of anxiety reported clinically meaningful improvements as compared to 22% of controls. Anxiety symptoms decreased on average 53% from baseline.
Improvements in Sleep Quality
60% of participants with sleep issues reported clinically meaningful improvements in sleep quality as compared to 15% of controls. Sleep quality improved on average 32% from baseline.
Improvements in Pain
51% of participants with symptoms of pain reported clinically meaningful improvements, with approximately 72% of participants reporting feeling better by the end of the study period. Pain symptoms decreased on average 28% from baseline.
Improvements in General Well-Being
Participants who took Charlotte’s Web Original Formula experienced a 74% improvement in indices of well-being as evaluated by the World Health Organization (WHO)-5 Well Being Index.
How Long Did It Take to See Effects?
This study also answered one of the most common questions healthcare practitioners have about hemp-derived CBD. It demonstrated that Original Formula worked quickly, with effect onset generally reported within four hours, and notable improvements occurring across all health outcomes on average within the first week.
In response to these findings, Tim Orr, President of CW (Charlotte’s Web) Labs, said, “As a hemp company driven by sound science, we were encouraged by the Radicle Science study. Independent third-party research and reporting on the efficacy of hemp wellness products help build long-term consumer trust and is an ongoing commitment of Charlotte’s Web.”
Jeff Chen, co-founder and CEO of Radicle Science, echoed the philosophy of Charlotte’s Web when he stated, “Our objective is to deliver accurate, transparent, and actionable insights to help create trust and transparency for the CBD industry.” Pelin Thorogood, co-founder and Executive Chair of Radicle Science added, “We are proud to partner with industry leaders such as Charlotte’s Web to inform evidence-based decision making for consumers, brands, healthcare providers, and regulators alike, increasing trust and transparency for the CBD industry.”
About Charlotte’s Web Original Formula
Original Formula is the flagship Charlotte’s Web full spectrum hemp extract that played a pivotal role in launching the CBD industry in the United States. It is still derived from the original hemp genetics and created using the same process that was developed for Charlotte Figi, the company’s namesake. Historically, Original Formula has been created using isopropyl alcohol (IPA) extraction. Alcohol is removed from the final product by a gentle heating process, and then re-used to prevent waste. IPA extraction is more labor intensive than standard CO2 extraction, which means Original Formula is produced in small, select batches. This small-batch, slow production process pays homage to how the company began. It also highlights the company’s dedication to providing healthcare practitioners with a range of options to best support individual patient biochemistry and wellness goals.
Original Formula provides 50mg of CBD per 1mL serving.